Module One: Rules and Filters and Their Impact on Success in Chemical Biology and Drug Discovery

Module Two: From Molecular Complexity to Molecular Obesity - Lessons From Hind Sight

Module Three: Practical Approaches to Fragment-Based Lead Discovery

Module Four: Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: From NMR-detected Fragment Hits to Clinical Candidate for BACE-1

Module One: Ion Channels: Basic Principles and Their Application to Assay Design

Module Three: Ion Channel Physiology and Drug Discovery

Module Two: Impact of Technology Evolution on Ion Channel Drug Discovery

Module One: MEMs Devices as Animal Alternatives for Tox, Drug Metabolism, and Sensitization Assessment

Module Two: New ADME-Tox Technologies: In Silico Approaches to Predictive ADME-Tox Evaluation

Module Three: In Vitro Models for the Study of Drug Transporters

Module Four: Application of Pharmacogenetics to Predictive ADMET

Module One: Biomarkers: Old, New, Improved, and Approved

Module Two: Discovery, Development, and Utilization of Protein Biomarkers to Improve Pharmaceutical Decision-Making and Increase Return on R+D Investm

Module Three: Utilizing SNPs to Identify High-Risk Men for Prostate Cancer Screening and Chemoprevention

Module Four: Quantitative Imaging Systems in Drug-Discovery Research: A Picture May Be Worth a Thousand Biomarkers

Module 1: Basic Pharmacological Principles, Agonism and the Operational Model

Module 2: Orthosteric and Allosteric Antagonism: Methods of Measurement

Module 3: Structure of Drug Discovery Programs: Target Selection, Assay Development and Criteria for Activity

Module 1: Primary Cells in Compound Screening: From Neurons to Novel Drug Candidate

Module 2: Preparation and Maintenance of Stem Cells and Primary Cells for Drug Discovery Initiatives

Module 3: Library Screening and Potential Therapeutic Applications of Stem Cell Preparations

Module 4: Reverse Engineering: Selected Techniques to Establish and Validate Targets Found by Phenotype Screening

Module 1: Introduction to the Principles of In Vitro ADME

Module 2: Drug Metabolism and Drug-Drug Interactions

Module 3: Safety/Toxicology Integrated Risk Assessment

Module 4: Major Elements of Organ-Toxicity

Module 1: Enzymes as Drug Targets and Actions of Inhibitors

Module 2: Measurement of Enzyme: Inhibitor Interactions

Module 3: Practical Kinetics for Elucidating Enzyme Mechanisms in Drug Discovery Part 1

Module 4: Practical Kinetics for Elucidating Enzyme Mechanisms in Drug Discovery Part 2

Module 1: The Power of Mass Spectrometry as a Label-Free Detection Platform

Module 2: Label Free Techniques To Assess Ligand Binding

Module 3: Cell-Based Assays Utilizing Label-Free Technologies

Module 1: Cells: Things to Remember

Module 2: Cells as Reagents

Module 3: Developing Cell-Based Assays for GPCRs and Ion Channels

Module 4: Cell-Based Assays for Pathway Analysis

Module 5: Cell-Based Assays for Target Validation

Medicinal Chemistry Concepts Mod 1: Introduction to Medicinal Chemistry: It’s all about the Molecules

Medicinal Chemistry Concepts Mod 2: Lead compounds:The Good, the Bad and the Ugly

Medicinal Chemistry Concepts Mod 3: Compound Optimization, Part 1: You Mean it’s More than Potency

Medicinal Chemistry Concepts Mod 4: Compound optimization, Part 2: Are We There Yet?

HTS Basics Module 1: Overview of Strategies and Methods in HTS

HTS Basics Module 2: Liquid Handling and Detection Technologies in HTS

HTS Basics Module 3: Statistical Considerations in the Optimization and Validation of HTS assays

HTS Basics Module 4: Issues in Storage and Management of Compound Collections

HTS Basics Module 5: HTS Case Studies and Lessons Learned

Module 1: The Kinome: Small Molecule Discovery and Pharmacology

Module 2: Cell based and Biochemical Assay Strategies for Kinase Screening and Profiling

Module 3: Chemical Library Development and Lead Optimization of Kinase Inhibitors

Module 4: Development and Clinical Trials for Kinase Targeted Compounds